Creating new medicines by enhancing protein function

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From protein function to cellular health

Unique approach
Broad potential
Powerful platform
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Our science

ENTACs are molecular matchmakers, bringing together target proteins with enzymes called DUBs. By recruiting the right DUB for each target, ENTACs harness the natural ability of DUBs to enhance protein function.

Target protein

Critical proteins that are in short supply, are in the wrong location, or have suboptimal activity

ENTAC

Enhancement-targeting chimeras are orally available, bifunctional small molecules

Dub

Deubiquitinases selectively remove ubiquitin molecules from target proteins

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Latest news & publications

02/07/2023 News Kelly Bilodeau

Entact Bio’s CEO is leading the company out of stealth and into a new age of protein enhancement

Guiding a young, groundbreaking company to maturity calls for a leader who can strike the right balance between oversight and support. Victoria Richon is hoping to provide just that as the new CEO of Entact Bio, a preclinical biotech that came out of stealth in December...

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01/06/2023 News Dylan Neel

Entact Bio: Victoria Richon, CEO

The language of drug development is often militaristic. Medicinal chemists build arsenals of small molecules—looking for inhibitors or “warheads” that can hit “targets” and “combat” disease. Block, eliminate, disrupt, halt. For decades, drug makers have sought “magic bullets” that can precisely destroy ...

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12/07/2022 News Gina Vitale

Entact Bio launches with $81 million to enhance protein function

When proteins within the body get tagged with a molecule called ubiquitin, they are essentially marked for destruction. But they can be saved; a deubiquitinase enzyme can remove the ubiquitin, keeping the protein intact. That, at least in part, is what Entact Bio aims to do...

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12/06/2022 News Ryan Cross

Biotech cofounded by Dana-Farber scientists launches with $81m for new approach to drugs

A small startup in Watertown has raised millions of dollars for early-stage research on a potentially powerful new idea that’s beginning to take hold in the biotech industry: designing drugs to enhance or prolong the function of helpful proteins that ward off disease. If successful, the approach could lead to new therapie...

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