Creating new medicines by enhancing protein function

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From protein function to cellular health

Unique approach
Broad potential
Powerful platform
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Our science

ENTACs are molecular matchmakers, bringing together target proteins with enzymes called DUBs. By recruiting the right DUB for each target, ENTACs harness the natural ability of DUBs to enhance protein function.

Target protein

Critical proteins that are in short supply, are in the wrong location, or have suboptimal activity


Enhancement-targeting chimeras are orally available, bifunctional small molecules


Deubiquitinases selectively remove ubiquitin molecules from target proteins

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Latest news & publications

11/07/2023 Publications Grant Dewson, Pieter J. A. Eichhorn & David Komander

Deubiquitinases in cancer

10/09/2023 Publications Anne Clancy, Emma V Rusilowicz-Jones, Iona Wallace, Kirby N Swatek, Sylvie Urbé, Michael J Clague

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

06/01/2023 Publications Indrajit Sahu, He Zhu, Sara J. Buhrlage, Jarrod A. Marto

Proteomic approaches to study ubiquitinomics

02/07/2023 News Kelly Bilodeau

Entact Bio’s CEO is leading the company out of stealth and into a new age of protein enhancement

Guiding a young, groundbreaking company to maturity calls for a leader who can strike the right balance between oversight and support. Victoria Richon is hoping to provide just that as the new CEO of Entact Bio, a preclinical biotech that came out of stealth in December...