From protein function to cellular health
Read more about ENTACs & Encompass
Most drugs inhibit proteins that contribute to disease. What if we could instead enhance proteins that can restore health?
Restore needed levels of a key protein by extending its lifespan
Relocate a misplaced protein to where it's needed in the cell
Change a protein's activity by altering its structure or interactions
ENTAC™ medicines enhance the function of key proteins to treat a broad range of diseases.
Target previously undruggable pathways
Address hard-to-treat genetic disorders
Treat common complex diseases
Our Encompass™ platform provides an end-to-end system for efficiently creating ENTACs.
Identify targets amenable to ENTAC intervention
Validate ENTAC-disease hypothesis
Design and optimize target-specific ENTACs
ENTACs are molecular matchmakers, bringing together target proteins with enzymes called DUBs. By recruiting the right DUB for each target, ENTACs harness the natural ability of DUBs to enhance protein function.
Read more about our science
Critical proteins that are in short supply, are in the wrong location, or have suboptimal activity
Enhancement-targeting chimeras are orally available, bifunctional small molecules
Deubiquitinases selectively remove ubiquitin molecules from target proteins
Who we are
We are scientists, entrepreneurs, drug creators, and problem solvers, all inspired by the idea that even when you’re ill there’s something intact within your cells that can help you get well.
Led by executives who have successfully transformed ideas into medicines, guided by scientific founders who have helped define the DUB field, and backed by investors with the courage to push drug development’s frontiers, we’re working together to bring ENTACs to the patients who need them most.Read more about our team
Latest news & publications
ISGylation-independent protection of cell growth by USP18 following interferon stimulation
Entact Bio’s CEO is leading the company out of stealth and into a new age of protein enhancement
Guiding a young, groundbreaking company to maturity calls for a leader who can strike the right balance between oversight and support. Victoria Richon is hoping to provide just that as the new CEO of Entact Bio, a preclinical biotech that came out of stealth in December...