Creating new medicines by enhancing protein function

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From protein function to cellular health

Unique approach
Broad potential
Powerful platform
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Our science

ENTACs are molecular matchmakers, bringing together target proteins with enzymes called DUBs. By recruiting the right DUB for each target, ENTACs harness the natural ability of DUBs to enhance protein function.

Target protein

Critical proteins that are in short supply, are in the wrong location, or have suboptimal activity


Enhancement-targeting chimeras are orally available, bifunctional small molecules


Deubiquitinases selectively remove ubiquitin molecules from target proteins

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Latest news & publications

05/29/2024 Press Releases

Entact Bio Appoints Michael Gutch, Ph.D., as Chief Operating Officer

Veteran pharma and biotech executive with 20 years of operations and finance experience joins world-leading team advancing novel targeted protein enhancement modality Watertown, MA, May 29, 2024 – Entact Bio, the pioneer of precision medicines that enhance the function of beneficial proteins, today announced the appo...

03/01/2024 Publications Bernhard C. Lechtenberg & David Komander

Just how big is the ubiquitin system?

11/07/2023 Publications Grant Dewson, Pieter J. A. Eichhorn & David Komander

Deubiquitinases in cancer

10/09/2023 Publications Anne Clancy, Emma V Rusilowicz-Jones, Iona Wallace, Kirby N Swatek, Sylvie Urbé, Michael J Clague

ISGylation-independent protection of cell growth by USP18 following interferon stimulation