Principal Scientist, Associate Director- Biology

About Us: Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitinase (DUB) biochemistry, chemical biology, disease biology, and small-molecule drug development, Entact has designed its proprietary Encompass™ platform to create enhancement-targeting chimeric (ENTAC™) medicines. ENTACs harness the ability of DUBs to regulate proteins. By leveraging this natural cellular mechanism to enhance protein function, Entact is expanding the universe of treatable diseases.


  • Key member of a biosciences team, providing leadership in designing and executing early drug discovery strategy
  • Lead a cross-functional team from target validation through lead optimization and candidate selection of a novel small molecule mechanism
  • Partnering with key stakeholders to develop program vision, strategy, compound evaluation, project scope, milestones, risk assessment and management strategies
  • Develop and lead collaborations with disease experts
  • Manage and coordinate external work at CROs
  • Effectively communicate scientific progress to all audiences, including investors, BOD, consultants, as well as internal audiences
  • Foster a culture of inclusion and scientific curiosity

Who You Are:

  • Exploratory: Relishing the early discovery space with a proven track record in driving programs from target validation to IND
  • Translational Research: Strong background in technologies such as NGS, RNA seq, Immunohistochemistry, flow cytometry commonly used for biomarkers discovery
  • Pharmacologist: Contribute to the design and conduct of in vivo and ex vivo studies in-house, with CROs, or with academic collaborators to enable advancement of candidate
  • Highly organized: Strong time management and planning skills
  • Highly collaborative: A teammate who thrives in a scientifically diverse, fast-paced, team-oriented, start-up environment
  • Driven and Conscientious: Able to effectively galvanize individual collaborators


  • PhD in a life science discipline and 7+ years’ industry experience
  • Expertise in drug discovery projects in oncology, immunology, and/or monogenic rare diseases
  • Track record of effective leadership in scientific teams that strategically drive programs to deliver drug candidates
  • Demonstrated knowledge of small molecule drug development, biomarker discovery, in vivo assessment of chemical matter to establish PK/PD and efficacy relationships
  • Strong understanding in multiple biochemical and molecular techniques including primary cell culture, genetic engineering, cell-based assays development, protein expression and flow cytometry required
  • Prior experience in leading development of a novel mechanism is considered a plus
  • Excellent communication skills with a proven ability to work with executive management

As a member of our diverse and growing team, you’ll help shape us into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion and talent – we’ll bring novel therapeutics to the patients who need them the most.


We are an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran's status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.



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