Our Science

At their core, ENTACs — enhancement-targeting chimeras — are molecular matchmakers. These small-molecule drugs bring together beneficial target proteins with enzymes called deubiquitinases, or DUBs, which are key regulators of protein function. DUBs work by selectively shortening or removing chains of a molecule called ubiquitin that are attached to proteins. Whether the target protein is in short supply, is in the wrong place within the cell, or has suboptimal activity, an ENTAC can be designed to recruit a DUB to fix the problem. By introducing each target to the right DUB, ENTACs enhance the function of these crucial proteins — many of which cannot be targeted with existing drugs — ultimately restoring the cell’s health.