Expanding the universe of treatable diseases by harnessing the cell's natural mechanism for enhancing protein function
ENTAC™ drugs in action
At their core, ENTACs — enhancement-targeting chimeras — are molecular matchmakers. These small-molecule drugs bring together beneficial target proteins with enzymes called deubiquitinases, or DUBs, which are key regulators of protein function. DUBs work by selectively shortening or removing chains of a molecule called ubiquitin that are attached to proteins. Whether the target protein is in short supply, is in the wrong place within the cell, or has suboptimal activity, an ENTAC can be designed to recruit a DUB to fix the problem. By introducing each target to the right DUB, ENTACs enhance the function of these crucial proteins — many of which cannot be targeted with existing drugs — ultimately restoring the cell’s health.
ENTACs bring specific target proteins together with specific DUBs...
...allowing the DUB to shorten or remove the target's ubiquitin chain.
Specific DUBs remove ubiquitin subunits in specific ways...
...enhancing the function of target proteins in specific ways.
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Our proprietary end-to-end Encompass platform integrates powerful biological, chemical, and computational tools to:
- Efficiently identify disease targets amenable to ENTAC intervention
- Select an optimal DUB to address the specific target
- Create specific ENTACs for each target-DUB pair
- Ubiquitin biology-disease atlas
- Target-specific ubiquitin toolbox
- Ubiquitin signaling expertise
- Proprietary chemistry
- Disease-specific assays
- Mechanistic validation
- DUB target specificity
- Tissue-specific DUB expression
- ENTAC compatibility
Latest news & publications
ISGylation-independent protection of cell growth by USP18 following interferon stimulation
Entact Bio’s CEO is leading the company out of stealth and into a new age of protein enhancement
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