Our Science

Expanding the universe of treatable diseases by harnessing the cell's natural mechanism for enhancing protein function

ENTAC™ drugs in action

At their core, ENTACs — enhancement-targeting chimeras — are molecular matchmakers. These small-molecule drugs bring together beneficial target proteins with enzymes called deubiquitinases, or DUBs, which are key regulators of protein function. DUBs work by selectively shortening or removing chains of a molecule called ubiquitin that are attached to proteins. Whether the target protein is in short supply, is in the wrong place within the cell, or has suboptimal activity, an ENTAC can be designed to recruit a DUB to fix the problem. By introducing each target to the right DUB, ENTACs enhance the function of these crucial proteins — many of which cannot be targeted with existing drugs — ultimately restoring the cell’s health.

Encompass platform

Our proprietary end-to-end Encompass platform integrates powerful biological, chemical, and computational tools to:

  • Efficiently identify disease targets amenable to ENTAC intervention
  • Select an optimal DUB to address the specific target
  • Create specific ENTACs for each target-DUB pair

TARGET SELECTION

TARGET SELECTION

  • Ubiquitin biology-disease atlas
  • Target-specific ubiquitin toolbox
  • Ubiquitin signaling expertise

ENTAC DESIGN

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ENTAC DESIGN

  • Proprietary chemistry
  • Disease-specific assays
  • Mechanistic validation

DUB SELECTION

DUB SELECTION

  • DUB target specificity
  • Tissue-specific DUB expression
  • ENTAC compatibility

Latest news & publications

03/01/2024 Publications Bernhard C. Lechtenberg & David Komander

Just how big is the ubiquitin system?

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11/07/2023 Publications Grant Dewson, Pieter J. A. Eichhorn & David Komander

Deubiquitinases in cancer

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10/09/2023 Publications Anne Clancy, Emma V Rusilowicz-Jones, Iona Wallace, Kirby N Swatek, Sylvie Urbé, Michael J Clague

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

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06/01/2023 Publications Indrajit Sahu, He Zhu, Sara J. Buhrlage, Jarrod A. Marto

Proteomic approaches to study ubiquitinomics

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